Delamere
JP, Jones GT. Changes in renal
function observed during a trek to high altitude
Postgraduate Medical Journal
1979; 55: 487-491
Changes
in renal function were observed in 17 subjects during the course of a trek to
high altitude. Comparison was made
between these changes and the clinical assessment of acute mountain sickness. (AMS).
Periods
of natriuresis occurred during ascent and descent, that during ascent being
related to a fall in plasma aldosterone. Alterations
in serum and urinary potassium suggested that potassium retention occurred
during the ascent to altitude.
No
significant correlation occurred between changes in renal function and the
severity of AMS before the illness being clinically apparent.
When this was so, the severity of AMS correlated with a decreasing urine
output, increasing positive fluid balance and a decreasing excretion of sodium
and potassium; these changed were produced in art by a decrease in glomerular
filtration rate.